1-(N-BOC-AMINOMETHYL)-3-(AMINOMETHYL) BE
TERT-BUTYL N-[3-(AMINOMETHYL)BENZYL]CARBAMATE
CAS: 108467-99-8
Molecular Formula: C13H20N2O2
1-(N-BOC-AMINOMETHYL)-3-(AMINOMETHYL) BE - Names and Identifiers
| Name | TERT-BUTYL N-[3-(AMINOMETHYL)BENZYL]CARBAMATE |
| Synonyms | N-Boc-3-(aminomethyl)benzylamine 1-(N-BOC-AMINOMETHYL)-3-(AMINOMETHYL) BE tert-Butyl 3-(Aminomethyl)benzylcarbamate tert-Butyl 3-(Aminomethyl)benzylcarbamate 1-(N-BOC-AMINOMETHYL)-3-(AMINOMETHYL)BENZENE TERT-BUTYL N-[3-(AMINOMETHYL)BENZYL]CARBAMATE N-tert-Butoxycarbonyl-1,3-bis(aMinoMethyl)benzene (3-AMINOMETHYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER N-[[3-(AMinoMethyl)phenyl]Methyl]carbaMic Acid 1,1-DiMethylethyl Ester |
| CAS | 108467-99-8 |
| InChI | InChI=1/C13H20N2O2/c1-13(2,3)17-12(16)15-9-11-6-4-5-10(7-11)8-14/h4-7H,8-9,14H2,1-3H3,(H,15,16) |
1-(N-BOC-AMINOMETHYL)-3-(AMINOMETHYL) BE - Physico-chemical Properties
| Molecular Formula | C13H20N2O2 |
| Molar Mass | 236.31 |
| Density | 1.06g/mLat 25°C(lit.) |
| Melting Point | 61-64 °C |
| Boling Point | 250°C(lit.) |
| Flash Point | >230°F |
| Solubility | Dichloromethane, Ethyl Acetate, Methanol |
| Vapor Presure | 4.45E-06mmHg at 25°C |
| Appearance | Oil |
| Color | Yellow |
| pKa | 12.21±0.46(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | n20/D 1.523(lit.) |
| Physical and Chemical Properties | WGK Germany:3 |
1-(N-BOC-AMINOMETHYL)-3-(AMINOMETHYL) BE - Risk and Safety
| UN IDs | UN3259 |
| WGK Germany | 3 |
1-(N-BOC-AMINOMETHYL)-3-(AMINOMETHYL) BE - Introduction
N-[3-(aminomethyl) benzyl] carbamic acid tert-butyl ester (chemical formula: C14H22N2O2) is an organic compound, often abbreviated as NBOMe, with the following properties:
-Appearance: NBOMe is a white crystalline solid;
-Solubility: It has certain solubility in common organic solvents;
-Melting point: about 100-120 degrees Celsius.
The main use of NBOMe is as a laboratory reagent and research chemicals to study the interaction between receptors and drugs in nerve conduction, the function of neurotransmitters, etc.
The preparation method of NBOMe is relatively complicated. Here is a brief introduction to a common synthetic route:
1. condensing benzylamine with formaldehyde to prepare N-benzylcarbinol amine;
2. Reaction of N-benzylcarbinol amine with tert-butyl alcohol ester to produce tert-butyl N-[3-(aminomethyl) benzyl] carbamate.
It should be noted that NBOMe and its preparation intermediates have high toxicity and irritation. They should be synthesized in a suitable laboratory environment and operating conditions, and the relevant safety operating procedures should be strictly followed.
-Appearance: NBOMe is a white crystalline solid;
-Solubility: It has certain solubility in common organic solvents;
-Melting point: about 100-120 degrees Celsius.
The main use of NBOMe is as a laboratory reagent and research chemicals to study the interaction between receptors and drugs in nerve conduction, the function of neurotransmitters, etc.
The preparation method of NBOMe is relatively complicated. Here is a brief introduction to a common synthetic route:
1. condensing benzylamine with formaldehyde to prepare N-benzylcarbinol amine;
2. Reaction of N-benzylcarbinol amine with tert-butyl alcohol ester to produce tert-butyl N-[3-(aminomethyl) benzyl] carbamate.
It should be noted that NBOMe and its preparation intermediates have high toxicity and irritation. They should be synthesized in a suitable laboratory environment and operating conditions, and the relevant safety operating procedures should be strictly followed.
Last Update：2024-04-09 19:05:44
